Job Description
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

We are seeking an exceptionally talented and highly motivated scientist to join our fast-paced Translational Sciences Mass Spectrometry Team. The successful candidate will be an expert in the field of targeted proteomics mass spectrometry, with a strong understanding of both biology and chemistry, and a demonstrated track record of independent research. In this role, the successful candidate will lead the effort of applying targeted proteomics in BMS clinical development and translational research to support target engagement, pharmacodynamic, mechanisms of drug action, and predictive biomarkers assay development. The successful candidate will collaborate with clinical and Translational Medicine Teams and other collaborators in developing, validating, and implementing targeted proteomics assays. The candidate will work on assays internally and with CROs. Strong technical and communication skills, adaptability and a collaborative style are necessary attributes for this role.

Qualifications

Ph.D. in Biochemistry, Biology, Analytical Chemistry, Proteomics or a related discipline with 5 -10 years relevant experience.
In-depth knowledge of current and emerging quantitative proteomics techniques relating to sample preparation, LC-MS data acquisition and analysis, including familiarity with MRM, PRM and DIA-based quantification methods, and with the analysis of post-translational modifications.
Very strong and hands on experience in method development for protein analysis on micro and nanoflow liquid chromatography systems and hybrid mass spectrometers (e.g. Thermo’s Q Exactive, Sciex’s Triple TOF 6600+ or Bruker’s TimsTOF Pro platforms etc.).
Extensive experience in targeted protein quantification for small to large protein panels.
Extensive experience in protein extraction and enrichment techniques for serum/plasma proteomics, such as protein fractionation/enrichment, abundant protein depletion, and solid phase extraction
Hands on experience in protein extraction for fresh tissues and FFPE samples is desirable.
Experience of immuno-capture LC-MS assay workflow, including immuno-capture with bead or cartridge formats, enzymatic digestion, and basic knowledge of ligand-binding assay (LBA) is a plus.
Proficient with contemporary proteomics software (e.g. MaxQuant, Skyline, Spectronaut, PaSER etc.). Familiarity with complicated data analysis and statistical concepts is a plus.
General knowledge in translational medicine strategies, biomarker and biology is a plus
Proven track record of scientific approach to complex problem solving as demonstrated in scientific publications and presentations
Basic knowledge of GCP, 21 CFR Part 11, FDA Bioanalytical Guidance
General knowledge of and interest in the drug discovery and development process.
Excellent written and oral communication skills, with demonstrated ability to write peer reviewed manuscripts and technical reports.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

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