Job Description

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Nonclinical Research and Development (NCRD) has an opening for a Senior Scientist, Non-clinical Disposition and Bioanalysis in Lawrenceville, NJ.

Nonclinical Research and Development (NCRD) is an integrated function with responsibility for characterizing nonclinical safety and disposition characteristics of the entire BMS Research and Development pipeline programs, with critical role from early discovery to submission of marketing authorization applications.  We utilize our deep expertise in toxicology/pathology, ADME, PK/PD and Bioanalytics in all modalities (small and large molecules, cellular therapies and other novel modalities) to collaborate with peer R&D functions to identify and solve issues, discover high quality drug candidates, enable their clinical development and successful marketing authorizations across the globe.

The successful candidate will be self-motivated, have good interpersonal and communication skills, be able to multi-task, be highly organized, have a strong desire to succeed in a multifunctional team setting, proven ability to meet goals working in a group of peers, and proven innovative thinking.

As it relates to ADME, the candidate will: 

• Design studies, develop protocols and conduct drug metabolism and biotransformation studies for BMS compounds in development.
• Act as a technical leader for internal drug metabolism/biotransformation studies performed within the group, especially with regard to mass spectrometry.
• Apply novel techniques and approaches to address ADME and drug disposition issues.
• Prepare ADME reports that go into submission documents such as CTD sections for INDs/NDAs, Investigator Brochures, briefing books.
• Keep management apprised of project status and current scientific trends using written and oral summaries, as well as presentations.

Skills/Knowledge Required:

• M.S. in Chemistry, Biochemistry, Pharmacology or Analytical Chemistry, or a related discipline with 4 to 6 years of industrial experience or Ph.D. in Chemistry, Biochemistry, Pharmacology or Analytical Chemistry, or a related discipline with 2 to 4 years of industrial experience
• Requires extensive knowledge of drug metabolism and hands-on mass spectrometry experience.
• Have hand-on experience conducting microsomal and hepatocyte incubations with C-14 or H-3 labeled compound for metabolism studies and have worked with in vivo samples from ADME/biotransformation studies.
• Broad based understanding of analytical techniques, especially high resolution mass spectrometry, used to characterize metabolic profiles, pharmacokinetics and drug interactions potential of drug candidates.
• Have experience preparing drug metabolism reports for regulatory submission.
• Strong written and verbal communication skills and computer proficiency are required.
• Ability to multi-task and work in a collaborative team environment.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. 

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation.  Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment.  This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.