Job Description

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.     

Position Summary

Leads Discovery and Optimization (LDO) is a diverse group of scientists and engineers providing critical lead discovery, lead evaluation, and lead profiling data to improve the understanding and increase the speed of discovery of new therapeutics.  The Discovery Analytics Sciences team in LDO will help shape the future of how we advance molecules to the clinic through rigorous understanding of binding affinity and stoichiometry.  We are seeking a highly motivated and creative Scientist to develop innovative models and analytical tools to enable portfolio decisions by addressing key scientific questions. This individual will join a creative team and work closely with other bench scientists to develop and run biophysical assays for hit assessment, mechanism of inhibition, and protein characterization. This position will report to a senior member of the DAS group.  Join us as we transform the drug discovery process to enable rapid progression of medicines to patients. 

Key Responsibilities

• Formulate hypotheses and develop innovative methods to address scientific questions within Small Molecule Drug Discovery using Biophysical tools and analyses
• Plan and carry out experimental studies, analyze and interpret data, and communicate conclusions with teams
• Develop and run Surface Plasmon Resonance (SPR), Microscale Thermophoresis (MST), and other biophysical binding assays for characterization of protein/ligand and protein/protein interactions
• Demonstrate solution binding of proteins with small molecule ligands and determine binding affinity and stoichiometry using microcalorimetry and related methods
• Characterize protein structure, stability, and aggregation state, using technologies such as microcalorimetry, spectroscopy, light scattering, analytical ultracentrifugation, etc.
• Use literature to solve basic scientific problems
• Work under limited supervision, routinely troubleshoot problems, and identify and pursue new ideas and solutions
• Participate on multidisciplinary project teams and make decisions that impact working groups and project teams
• Communicate results written and verbally to drug discovery working groups, logically explain issues, and work to build alignment around complex situations
• Maintain a complete and current Electronic Laboratory Notebook
• Present work in departmental meetings and across research & early development organization
• Present analyses and results to technical and non-technical audiences
• Participate in evaluation of new technologies and instrumentation
• May represent the department in interdepartmental forums and sub-teams
• May act as a functional mentor to junior team members and contractors

Qualifications & Experience

• PhD in Biochemistry, Biophysics, or related field with 1-3 years relevant experience or MS/BS with 4-6 years of experience, preferably in a Biotech, Pharma or Biopharma setting.
• Thorough knowledge of quantitative analysis of protein-ligand interactions, robust method development and strong experience using either surface plasmon resonance (SPR) or microscale thermophoresis (MST) is necessary.
• Familiarity with automation, electronic lab notebook and laboratory information management system (LIMS) systems is a plus.
• Knowledge of principles of biophysical characterization of proteins such as oligomeric structure and stability using microcalorimetry, fluorescence or other spectroscopy, light scattering or other related technologies, TSA, or analytical ultracentrifugation would be advantageous.
• Experience with protein analytical characterization techniques such as SDS-PAGE, analytical size exclusion chromatography (SEC), liquid chromatography mass spectrometry (LC-MS) is a plus.
• Experience with high throughput screening methods, and/or recombinant protein purification including method development, optimization and troubleshooting would be an advantage.
• An interest in the drug discovery process is expected.
• Excellent communication skills, evidence of innovative thinking, and ability to function at a high level in a matrixed environment are necessary, as is proficiency in scientific/technical writing (e.g., scientific reports, protocols).

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. 

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation.  Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment.  This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

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